Severe abdominal manifestations in juvenile dermatomyositis

Juvenile dermatomyositis (JDM) is a rare and heterogeneous pediatric-onset idiopathic inflammatory myopathy. Gastrointestinal (GI) involvement occurs in 22% to 37% of JDM patients but has only been described in case reports.

In this retrospective, single-center, observational study, the authors aimed to assess the causes and management of severe GI manifestations in JDM patients. They studied a cohort of 9 patients among 110 JDM patients followed during the study period (8.3%). The GI complications were related to JDM in most cases (17/19), with digestive tract involvement (n = 10), acute pancreatitis (n = 4), and hepatitis (n = 3). Three patients died from refractory JDM 2.9 years (2-3.6) after the JDM diagnosis.

The clinicians highlight the need to consider pancreatitis as a main diagnostic factor in JDM patients with severe GI manifestations and the requirement of early aggressive treatment for these patients.


Severe abdominal manifestations in juvenile dermatomyositis Besnard C, Gitiaux C, Girard M et al. J Pediatr Gastroenterol Nutr. 2020 February