Exercise is known to improve muscle health and strength in healthy individuals with Duchenne muscular dystrophy (DMD), as well as positively impact other systems. Because of this, exercise has been investigated as a potential therapeutic approach for DMD. This review aims to provide a concise presentation of the exercise literature with a focus on dystrophin deficient muscle. The paper highlights that endurance exercises such as a swimming and voluntary wheel running have therapeutic potential in limb muscles of mice and respiratory training was beneficial in humans. However, in the comparatively few long-term investigations, the effect of low intensity training on cardiac and respiratory muscles was contradictory. In addition, the effect of exercise on other systems is largely unknown.
