Research exploring the effects of physical exercise in auto-immune myasthenia gravis (MG) is scarce. The few existing studies present methodological shortcomings limiting the conclusions and generalisability of results. It is hypothesised that exercise could have positive physical, psychological as well as immunomodulatory effects and may be a beneficial addition to current pharmacological management of this chronic disease. Here, the authors describe the design and methods of MGEX, a multi-centre, two-arm, parallel group, randomised, controlled trial investigating the tolerance and potential benefits of a moderate-intensity, individualised, home-based physical exercise program in adults with generalised, stable, MG. This is the first study to explore physical exercise in this population with such a large sample size and rigorous methodological design.
