Effect of aerobic anti-gravity exercise in patients with Charcot-Marie-Tooth disease types 1A and X

 

Charcot-Marie-Tooth (CMT) disease is a hereditary neuropathy associated with impaired walking capacity. Some patients are too weak in the lower extremity muscles to walk at gravity with sufficient intensity or duration to gain benefit. The aim of this pilot study was to investigate the effect of aerobic anti-gravity exercise in weak patients with CMT 1A and X. Five adult patients performed moderate-intensity aerobic anti-gravity exercise 3/week for 10 weeks. There was a significant positive difference in Berg balance scale and postural stability test between test occasions, and walking distance in the 6-min walk test trended to increase.

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Knak KL, Andersen LK, Vissing J. Aerobic anti-gravity exercise in patients with Charcot-Marie-Tooth disease types 1A and X: A pilot study. Brain Behav. 2017 Nov 2;7(12):e00794.