Effect of gender, disease duration and treatment on muscle strength in myasthenia gravis

PLoS one logo bleuThis observational, cross-sectional study quantified the potential presence of muscle weakness among 107 patients with generalized myasthenia gravis (gMG) and 89 healthy age- and gender-matched controls. The influence of gender, treatment intensity and disease duration on muscle strength and disease progression was also assessed. The main findings of this study show that: 1) patients with gMG have a significant, generalized muscle weakness, 2) men are weaker than women with gMG, 3) weakness is most pronounced in proximal muscle groups, and 4) disease duration or treatment intensity alone are not predictors of loss of muscle strength in gMG.

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Citirak G, Cejvanovic S, Andersen H, Vissing J. Effect of Gender, Disease Duration and Treatment on Muscle Strength in Myasthenia Gravis. PLoS One. 2016 Oct 14;11(10):e0164092.