Inflammatory myopathies
RSS feedIdiopathic myositis: an increased and early risk of cardiovascular events in cases of cardiac involvement at diagnosis
The Hôpital Saint-Antoine (Paris) conducted a retrospective study between 1997 and 2020 of 78 patients with idiopathic inflammatory myopathy (myositis). Of these, 42% had dermatomyositis, 23% had antisynthetase syndrome, 15% had overlapping myositis, 14% had necrotising myopathy and 5% had inclusion myositis. Cardiac involvement was present in 15% of patients at the time of myositis … [Read more]
FSHD combined with genuine myositis: an intriguing association
A French study involving clinicians from the Institute of Myology reports several new and disturbing cases of patients with two co-existing neuromuscular pathologies: firstly, facioscapulohumeral muscular dystrophy (FSHD), proven by molecular biology, and secondly, myositis authenticated by the presence of specific autoantibodies, of the 5 cases of this type identified in the myositis database of … [Read more]
Dermatomyositis and cancer are significantly associated
A French multicentre retrospective study of 73 patients with cancer-associated dermatomyositis, followed for an average of 3.92 years, involving experts from the Institute of Myology, showed that : 82.2% had classic dermatomyositis, 8.2% had amyopathic dermatomyositis and 9.6% had hypomyopathic dermatomyositis; 76.7% had been diagnosed with cancer in the year preceding or following the onset … [Read more]
NDUFA11, a possible autoantigen in inclusion body myositis
An international study involving the Nice University Hospital and the Pitié-Salpêtrière Hospital : evaluated IgG reactivity to a panel of 357 proteins in a total of 874 people, including 31 with sporadic inclusion myositis; IgG anti-NDUFA11 (for NADH dehydrogenase 1 α subcomplex 11) was found to be more frequent in inclusion myositis (9.7% of cases) … [Read more]
The type of muscle damage has no influence on the prognosis of scleroderma
A multicentre retrospective study of 71 scleroderma patients who had undergone muscle biopsy found 46.5% with fibrosing myopathy, 25.5% with inflammatory myopathy and 28% with autoimmune necrotising myopathy. During follow-up, which averaged 6.4 years, 21 patients died, mainly from cardiovascular disease (39%) or infections (29%). The survival rate 10 years after the appearance of the … [Read more]
Belgian family confirms possible link between HLA-DRB1*11:01 and statin-induced myositis
In Belgium, a father and daughter : developed autoimmune necrotising myopathy with HMGCR autoantibodies a few years apart, following treatment with statins; are both carriers of HLA-DRB1*11:01, a variant already identified as being more frequent in this disease. The case of this Belgian family strengthens the hypothesis of genetic susceptibility to autoimmune myositis. Investigation of … [Read more]
Beware of phytotherapies in dermatomyositis
American clinicians have studied the prevalence and risk-taking among patients suffering from cutaneous autoimmune diseases who use herbal treatments: These included dermatomyositis and systemic lupus erythematosus (SLE), 673 adult patients consulting the University of Pennsylvania between 2007 and 2024 were included in a retrospective study, a third of the patients, particularly younger patients and Hispanics, … [Read more]
Positive feedback on multidisciplinary management of interstitial lung disease in France
Patients with certain inflammatory myopathies are at risk of developing severe interstitial lung disease. French clinicians working in the FAI2R and RespiFil healthcare networks report on their experience after setting up a multidisciplinary unit to help practitioners in the field confronted with this problem: this unit is made up of lung specialists, internists, rheumatologists, radiologists, … [Read more]
Granulomatous myositis: a rare form of inflammatory myopathy
French researchers report the clinical and histological data and immunological profile of 26 patients diagnosed with granulomatous myositis: the age of onset was generally very late (median age 65), with clinical severity observed in half the cases, in 14 out of 26 cases, the etiology was sarcoidosis, and more rarely other causes (inclusion myositis, paraneoplastic … [Read more]
Overview of the main myopathies that can begin in the over-50s
A French review has set out to provide an overview of the most emblematic late-onset myopathies (LOMs), those which may appear after the age of 50, and to identify the pitfalls to be avoided and the important steps in the diagnostic approach to these pathologies. Based on an assessment of the literature and medical data … [Read more]
