Inflammatory myopathies
RSS feedNew developments in the treatment of certain refractory inflammatory myositis
German clinicians report a case of antisynthetase syndrome (ASyS) treated with several biotherapies: the patient, aged 45, had ASyS with signs of joint, muscle (myositis) and respiratory (interstitial lung disease) disease, with the presence of autoantibodies directed against the Jo-1 antigen, an initial treatment with CAR-T cells directed against CD19 lymphocytes resulted in remission for … [Read more]
Towards a better understanding of the side effects associated with the use of CAR-T cells
German clinicians have studied adverse side effects in patients with autoimmune diseases who have received CAR-T cells targeting the CD19 antigen: 39 adult patients, including six with inflammatory myopathy of autoimmune origin, were selected for this retrospective study. 30 of them developed a cutaneous and/or renal intolerance syndrome within 10 days of CAR-T cell injection. … [Read more]
Clinical presentations of immune-mediated necrotizing myopathy need to be better recognised
American clinicians, including Andrew Mammen, the researcher behind the first descriptions of immune-mediated necrotizing myopathy (IMNM), take stock of this pathology and highlight its atypical forms: after recalling the usual framework of this myopathy characterised by muscle weakness and the positivity of autoantibodies against the SRP and/or HMGCR proteins, the authors have compiled the atypical … [Read more]
The association of dermatomyositis and encephalopathy is exceptional but should be noted
Mexican clinicians report the clinical and immunological data of three patients with concomitant encephalopathy and dermatomyositis (DM): the three patients were adults in their fifties with no previous history of the disease, all met the criteria for dermatomyositis, including the presence of myositis-specific antibodies (in particular MDA5, Mi2 and TIF1g), the clinical picture included sub-acute … [Read more]
The benefit of reusing data from placebo groups in inclusion myositis
American researchers associated with the Institute of Myology Research Centre have compiled and re-analysed the data accumulated in the placebo arms of several clinical trials in inclusion myositis (IMM) : 11 therapeutic trials were selected, they involved 257 participants who had received only a placebo, the main endpoints were changes in muscle strength and, in … [Read more]
Immune-mediated necrotising myopathy in children, a Chinese picture
A study conducted by a hospital in Beijing (China) has refined our knowledge of the phenotype of immune-mediated necrotising myopathy in paediatrics: 55 of the 116 children and adolescents followed up for myositis by this centre between 2012 and 2024 had immune-mediated necrotising myopathy, a much higher proportion (47.4%) than expected, but one that would … [Read more]
Idiopathic myositis: an increased and early risk of cardiovascular events in cases of cardiac involvement at diagnosis
The Hôpital Saint-Antoine (Paris) conducted a retrospective study between 1997 and 2020 of 78 patients with idiopathic inflammatory myopathy (myositis). Of these, 42% had dermatomyositis, 23% had antisynthetase syndrome, 15% had overlapping myositis, 14% had necrotising myopathy and 5% had inclusion myositis. Cardiac involvement was present in 15% of patients at the time of myositis … [Read more]
FSHD combined with genuine myositis: an intriguing association
A French study involving clinicians from the Institute of Myology reports several new and disturbing cases of patients with two co-existing neuromuscular pathologies: firstly, facioscapulohumeral muscular dystrophy (FSHD), proven by molecular biology, and secondly, myositis authenticated by the presence of specific autoantibodies, of the 5 cases of this type identified in the myositis database of … [Read more]
Dermatomyositis and cancer are significantly associated
A French multicentre retrospective study of 73 patients with cancer-associated dermatomyositis, followed for an average of 3.92 years, involving experts from the Institute of Myology, showed that : 82.2% had classic dermatomyositis, 8.2% had amyopathic dermatomyositis and 9.6% had hypomyopathic dermatomyositis; 76.7% had been diagnosed with cancer in the year preceding or following the onset … [Read more]
NDUFA11, a possible autoantigen in inclusion body myositis
An international study involving the Nice University Hospital and the Pitié-Salpêtrière Hospital : evaluated IgG reactivity to a panel of 357 proteins in a total of 874 people, including 31 with sporadic inclusion myositis; IgG anti-NDUFA11 (for NADH dehydrogenase 1 α subcomplex 11) was found to be more frequent in inclusion myositis (9.7% of cases) … [Read more]
