Blog Archives
Is corticosteroid therapy effective on cardiac function in DMD? Review
Chinese researchers wanted to know whether the long-term corticosteroid therapy used in Duchenne muscular dystrophy (DMD) could improve cardiac function: their work is based on a critical review of studies in the field published between 2000 and 2024, 21 studies were selected, 13 of which, corresponding to 1,814 DMD patients, argued in favour of a … [Read more]
M&M’s – Muscle Monday Seminar – 30 June – Kay Ohlendieck (Ireland)
Proteomic profiling of skeletal muscle aging Monday 30 June 2025 – 12h00-13h00 Pr Kay Ohlendieck (Maynooth University Faculty of Science & Engineering, Ireland) More information on the presentation and the speaker On prior registration for people outside the Institute of Myology: medecine-umrs974-myologie@sorbonne-universite.fr M&M’s seminar organised by the Center of Research in Myology, at the … [Read more]
An optimised version of gene therapy being studied in SMA
Beijing researchers report the results of preclinical studies on a new-generation gene therapy for SMA: the new transgene (AAV9-coSMN1) contains an optimised codon, carried by an adeno-associated virus of the AAV9 type, mice from the Taiwanese model and non-human SMA primates were used and studied after intrathecal injection of the transgene, this modification in the … [Read more]
Clinical presentations of immune-mediated necrotizing myopathy need to be better recognised
American clinicians, including Andrew Mammen, the researcher behind the first descriptions of immune-mediated necrotizing myopathy (IMNM), take stock of this pathology and highlight its atypical forms: after recalling the usual framework of this myopathy characterised by muscle weakness and the positivity of autoantibodies against the SRP and/or HMGCR proteins, the authors have compiled the atypical … [Read more]
Satish B. Moparthi, co-winner of the ‘Grandes Avancées Françaises en Biologie’ award from the French Academie des Sciences
Satish Babu Moparthi, a post-doctoral fellow in the ‘Muscle cell organisation and therapy of centronuclear dominant myopathy’ team at the Center of Research in Myology of the Institute of Myology, co-directed by Stéphane Vassilopoulos, has been awarded the 2025 Grandes Avancées Françaises en Biologie (GAFB) prize, along with Florian Werner, co-author of the article* published … [Read more]
Long-term efficacy of nusinersen varies according to the frequency of injection
Japanese researchers have compared two protocols, Japanese and European, for administering nusinersen in the treatment of SMA: for regulatory reasons, the Japanese protocol involves only two intrathecal injections of nusinersen as a loading dose, followed by injections every 6 months instead of every 4 months in the European protocol, 14 Japanese adults with SMA took … [Read more]
Risdiplam tablets approved at European level
Already available in the oral solution form, which can be stored in the refrigerator or, exceptionally, at room temperature for up to 5 days, risdiplam (Evrysdi) has now also been authorised at European level in a new galenic form: Roche has announced that the European Commission has authorised 5 mg tablets, for patients with proximal … [Read more]
A case of acquired and reversible rod myopathy following leukaemia
Researchers at the Créteil Neuromuscular Disease Reference Centre report the rather exceptional case of a patient who developed myopathic symptoms during an immunological complication (graft-versus-host disease or GVHD) that occurred during treatment for leukaemia: the 49-year-old patient was being treated for acute leukaemia with chemotherapy and an allograft when she developed concomitant GVHD and myopathic … [Read more]
The corner stone of our Foundation of Myology was laid on 17 June
On Tuesday 17 June, we laid the corner stone for our future Foundation of Myology, the first foundation worldwide dedicated to muscle research, in the presence of Jérome Coumet, Mayor of the 13th arrondissement of Paris and Chairman of SEMAPA, Lamia El Aaraje, Deputy Mayor of Paris responsible for urban planning, architecture of Greater Paris, … [Read more]
Exploring the infinitely small – Interview with Stéphane Vassilopoulos
An expert in cell biology and molecular biology, Stéphane Vassilopoulos is co-director of the ‘Muscle cell organization and therapy of dominant centronuclear myopathy‘ team at the Institute’s Center of Research in Myology. Seeking to understand why and how the alteration of certain muscle proteins leads to dysfunction and then disease, he and his team have … [Read more]
