Blog Archives
AcadeMYO 9-11 December 2024 online
Join us for this unique opportunity to perfect your skills in myology, an increasingly exciting discipline dedicated to neuromuscular science! All professionals manifesting some interest in the field are encouraged to apply. Be prompt in doing so as the maximal gauge has been set to 100 participants this year. ➢ Watch this space for the … [Read more]
Review of gene therapy approaches in CMT
An increasing number of gene therapy products are being developed for Charcot-Marie-Tooth disease. This article provides an overview of the main approaches under study: a single phase I/II trial is underway in the United States in CMT 2S, involving 10 patients, twelve products are in preclinical development, for which the choice of vector and route … [Read more]
30 September: International LGMD Awareness Day
The 10th International Limb Girdle Muscular Dystrophy Awareness Day will take place on 30 September. Organised by the LGMD Awareness Foundation, the aim of this day is to draw attention each year to this group of rare neuromuscular diseases that have an impact on the lives of many people, children and adults alike, in every … [Read more]
A unique microscopy technology has revealed previously unknown mechanisms of endocytosis in the axon – Interview with Stéphane Vassilopoulos
Satish Babu Moparthi, post-doctoral fellow, and Stéphane Vassilopoulos, co-director of the ‘Muscle cell organization and therapy of dominant centronuclear myopathy‘ team at the Research Centre of the Institute of Myology, have just published an article in the journal Science* in collaboration with Christophe Leterrier’s team (Aix-Marseille University, CNRS). Using a combination of two cutting-edge technologies, they … [Read more]
Cardiovascular damage in McArdle’s disease
A review of the literature on cardiovascular damage in McArdle disease, or type V glycogenosis, shows that : 21 cases have been described, including 18 men, most often with coronary artery disease (17 cases), or, more rarely, hypertrophic cardiomyopathy. The authors of this review therefore recommend regular cardiac monitoring in McArdle’s disease. Cardiac comorbidities … [Read more]
21 September: International Myositis Awareness Day
Every year since 2001, 21 September has been International Myositis Awareness Day. Myositis is an autoimmune muscle disease that can affect adults and children. It causes weakness, muscle wasting and fatigue, and sometimes affects the skin, heart and lungs. There are different forms of the disease (dermatomyositis, inclusion myositis, etc.), with different mechanisms and symptoms. … [Read more]
Fête de la Science from 4 to 14 October
Organised every year by the Ministry of Higher Education and Research, the event aims to give everyone the chance to discover the world of science and meet the men and women who make up today’s science. This year’s Fête de la science runs from 4 to 14 October 2024. The AFM-Téléthon is taking part in … [Read more]
Losmapimod fails in facioscapulohumeral myopathy
The initial results of the REACH Phase III placebo-controlled trial evaluating losmapimod in 260 adults with FSHD1 or FSHD2 over one year have just been announced by the Fulcrum Therapeutics laboratory in charge of its development, and they’re not good. Losmapimod failed to meet the trial’s main endpoint, namely to improve measurement of the relative … [Read more]
The Fondation Leducq has recently awarded funding to the PRIORITY international network of excellence, coordinated by Dr Gisèle Bonne.
The PRIORITY international network of excellence has just been awarded an $8,000,000 grant from the Fondation Leducq. PRIORITY is a research consortium of 8 partners, 4 from Europe and 4 from North America*, which will work on LMNA gene-related dilated cardiomyopathy (LMNA-DCM). PRIORITY will be coordinated by Dr Gisèle Bonne (Institut de Myologie, France) and … [Read more]
The relationship between muscle strength and function in the upper limb now better established in DMD and SMA
Researchers coordinated by the Institute of Myology have studied the threshold of muscle strength loss beyond which motor function is compromised in the hand: 91 patients with Duchenne muscular dystrophy (DMD) and 77 with SMN1-related proximal spinal muscular atrophy (SMA) took part in the study, hand grip strength and thumb-index grip strength were measured using … [Read more]
