Blog Archives
Myology 2019: the scientific program of the congress is now online
The detailed program of the Myology 2019 congress to be held from 25 to 28 March 2019 in Bordeaux is now online. The congress begins on Monday with the opening ceremony followed by the opening conference. For the following days, each half-day consists of a plenary session and two parallel sessions. On Tuesday afternoon, the … [Read more]
Diagnosis of respiratory diseases: Development of a new non-invasive method for the evaluation of diaphragm function
A team from the Institute of Myology has developed, in collaboration with a team from the Sorbonne University and the French Public Health and Hospital system, a non-invasive method to evaluate the function of the diaphragm, the main breathing muscle. This new method could represent an alternative to standard invasive methods, which rely on the … [Read more]
Nuclear defects in skeletal muscle from a Dynamin 2-linked centronuclear myopathy mouse model
Dynamin 2 (DNM2) is a key protein of the endocytosis and intracellular membrane trafficking machinery. Mutations in the DNM2 gene cause autosomal dominant centronuclear myopathy (CNM) and a knock-in mouse model expressing the most frequent human DNM2 mutation in CNM (Knock In-Dnm2R465W/+) develops a myopathy sharing similarities with human disease. Using isolated muscle fibres from … [Read more]
Pluripotent Stem Cell-Based Drug Screening Reveals Cardiac Glycosides as Modulators of Myotonic Dystrophy Type 1
There is currently no treatment for myotonic dystrophy type 1 (DM1), the most frequent myopathy of genetic origin. This progressive neuromuscular disease is caused by nuclear-retained RNAs containing expanded CUG repeats. These toxic RNAs alter the activities of RNA splicing factors, resulting in alternative splicing misregulation. By combining human mutated pluripotent stem cells and phenotypic … [Read more]
Therapeutic regimen of L-arginine for MELAS: 9-year, prospective, multicenter, clinical research
In this study, the authors examined the efficacy and safety of the therapeutic regimen using oral and intravenous L-arginine for pediatric and adult patients with mitochondrial myopathy, encephalopathy, lactic acidosis, and stroke-like episodes (MELAS). In the presence and absence of an ictus of stroke-like episodes within 6 h prior to efficacy assessment, we correspondingly conducted … [Read more]
Positive results of an Omega-3 trial in DMD
Duchenne Muscular Dystrophy (DMD) is the most prevalent dystrophy of childhood and is characterized by generalized motor delays due to progressive muscular weakness, leading to loss of muscle mass. Additionally, patients with DMD develop obesity, hyperinsulinemia, and Insulin Resistance (IR). Omega-3 Long-Chain PolyUnsaturated Fatty Acids (Ω-3LCPUFA) increase fat mass, decrease lean mass, and decrease hyperinsulinemia … [Read more]
The Institute of Myology is looking for a Project Assistant (M / F)
Supervised by the Coordinator and project manager the main objective of this post is to provide support to the European Reference Network, EURO-NMD, and the Coordination team. This role will provide administrative support to the Coordination team at the Institut de Myology. > Download the complete annoucement of Project Assistant (M / F)
Institute seminar – 11 February – Beatriz Llamusi, PhD (Spain)
Therapeutic targeting of MBNL microRNAs as innovative treatments for myotonic dystrophy Monday 11 February 2019 – 12:00-13:00 Beatriz Llamusi, PhD (University of Valencia, Interdisciplinary Research Structure for Biotechnology and Biomedicine (ERI BIOTECMED), Valencia, Spain; Translational Genomics Group, Incliva Health Research Institute, Valencia, Spain; Joint Unit Incliva-CIPF, Valencia, Spain) Host : Denis Furling Institute of Myology auditorium … [Read more]
The Institute of Myology is looking for a Project Manager (M / F)
This management post within the Institute of Myology leads the strategic development and delivery of the EU-funded project European Reference Network (ERN) EURO-NMD to ensure the deliverables and objectives of this multinational project are achieved. This role will require an overarching view on all relevant international activities and liaising closely with key stakeholders to ensure … [Read more]
Release of the 71th newsletter from the Institute
The Institute of Myology wishes you a successful 2019 Welcome to the first issue of our newsletter for the new year! Victory was the theme of the 2018 Telethon and the Institute of Myology can be proud of its own victories, which undoubtedly contribute to the whole. The year 2018 has been rich … [Read more]
