Blog Archives
AcadeMYO 2022: registration opens on 1st June
AcadeMYO, the digital version of the Summer School of Myology, will take place from 11 to 13 July 2022. Registration will be possible from June 1st on the AcadeMYO website. AcadeMYO comprises pre-recorded lectures (40 from the 2021 edition with 20 additional lectures in 2022) and three live interactive sessions of 4 hours on average each, … [Read more]
New roles for CaVβs subunits in the regulation of gene expression and cellular homeostasis
. Voltage-gated calcium channels (CaVs or VGCCs) regulate intracellular calcium homeostasis. . Their activation by electrical activity leads to changes in intracellular Ca2+ levels regulating, depending on the cell type, various processes such as contraction, secretion and gene expression. . While the CaVα1 subunit is the essential component of the calcium channel, the auxiliary β, … [Read more]
The institute was present at the 14th MGFA International Conference on Myasthenia and Related Disorders
The 14th International Conference on Myasthenia Gravis and Related Disorders organised by the Myasthenia Gravis Foundation of America (MGFA) took place from 10 to 12 May 2022 in Miami, USA. It brought together the best experts in myasthenia, including the researchers of team 7 “Myasthenia Gravis: Etiology, Physiopathology & Therapeutical Approaches” of the Institute’s Myology … [Read more]
A post-doctoral position is available at the Institute’s Myology Centre for Research
A two-year fully funded post-doctoral fellowship position sponsored by ANR will be available at the Myology Research Center in the group of Stéphane Vassilopoulos to assess the structure/function relationship of clathrin structures in mechanotransduction and endocytosis. The main objective is to reveal the mechanisms by which muscle cells form clathrin plaques using alternative splicing isoforms … [Read more]
Researchers from the Institute’s NMR laboratory at the ISMRM 2022 conference
The 31st ISMRM (International Society for Magnetic Resonance in Medicine) congress was held in London from 7 to 12 May 2022. Researchers from the NMR Imaging and Spectroscopy Laboratory were able to present their results during several sessions, via digital posters and an oral presentation: Benjamin Marty : Assessment of skeletal muscle extracellular volume fraction … [Read more]
Launch of the 1st European gene therapy clinical trial in LGMD linked to FKRP
The first European gene therapy trial in limb-girdle muscular dystrophy linked to the FKRP gene (LGMD2I/R9) has just started. This is a multicentre phase 1-2 study evaluating the safety, pharmacodynamics, efficacy and immunogenicity of GNT0006, an adeno-associated virus (AAV) vector carrying the human FKRP transgene. This study will consist of two phases: an open-label dose … [Read more]
€ 68,000 raised through the HOPE dance gala
We are proud and very grateful to have received on 18 May Laura Arend, Christian Arend and Charlotte Ranson who presented us with the generous sum of € 68.000. This sum was raised through the HOPE dance gala dedicated to muscle research. Orchestrated by Laura, Charlotte and their companies, the show took place last October … [Read more]
Andersen-Tawil syndrome: phenotypical variability and atypical presentations in a French cohort
Andersen-Tawil syndrome (ATS) is a rare muscle channelopathy linked to mutations in the KCNJ2 gene. This syndrome combines to varying degrees the clinical triad of periodic paralysis, cardiac arrhythmias and dysmorphic syndrome. The muscle phenotype is still being characterised. A French study, involving clinicians from the Institute, was carried out on 35 patients with ATS … [Read more]
Effects of Prox1 overexpression in mdx dystrophic muscle
In Duchenne muscular dystrophy, increased muscle fragility appears to be the cause of muscle stem cell depletion, which leads to muscle wasting and thus muscle weakness. Chronic voluntary exercise can reduce some of the susceptibility to contraction-induced muscle damage, that is muscle fragility. In this paper, a French team involving researchers from the institute studied the … [Read more]
Endothelin: a new player in muscle fibrosis – Interview with Capucine Trollet
Mona Bensalah completed her thesis under the supervision of Elisa Negroni and Vincent Mouly in the team “Cellular and molecular orchestration in muscle regeneration, during aging and in pathologies” directed by Capucine Trollet and Vincent Mouly, at the Institute’s Myology Research Centre. Her work, completed by that of Laura Muraine, has just been published in … [Read more]
