Blog Archives
Searching for the optimal corticosteroid therapy in DMD
Although long-term corticosteroid therapy is a commonly accepted standard of care in Duchenne muscular dystrophy (DMD), its modalities are still debated. An essai international multicentrique attempted to answer this question by comparing several types of corticosteroids in a population of 196 children. Participants were randomly assigned to one of three groups: daily prednisone (0.75 mg/kg/day), … [Read more]
A therapeutic approach for polyglucosan or glycogen overload diseases
Adult polyglucosan inclusion disease (APBD) and Lafora’s disease are two neurological diseases with an overload of abnormal glycogen (polyglucosan). In the absence of a branching enzyme, as in APBD, glycogen does not branch and elongation of the glycogen chain by glycogen synthase results in the accumulation of insoluble polyglucosan. By inhibiting the expression of the … [Read more]
Our Myology Centre for Research offers a post-doctoral fellowship in muscle cell biology
We are looking for a highly motivated and creative muscle cell biologist to join our lab. The post-doctoral fellowship position is funded by an EQUIPE FRM grant and is open with a flexible starting date until September 2022. Research topic The project aims at studying cell communication during human skeletal muscle regeneration in aging … [Read more]
Almost one third of BMD patients have cognitive or neuropsychiatric disorders
An Italian team conducted a review of the literature published after 1995 on cognitive, behavioural and psychosocial disorders in people with Becker muscular dystrophy (BMD). The meta-analysis included 11 publications, included five focused on central nervous system disorders in BMD and five multicentre or registry studies. Across all studies, the distribution of intelligence quotient (IQ) … [Read more]
AcadeMYO 2022: registration opens on 1st June
AcadeMYO, the digital version of the Summer School of Myology, will take place from 11 to 13 July 2022. Registration will be possible from June 1st on the AcadeMYO website. AcadeMYO comprises pre-recorded lectures (40 from the 2021 edition with 20 additional lectures in 2022) and three live interactive sessions of 4 hours on average each, … [Read more]
New roles for CaVβs subunits in the regulation of gene expression and cellular homeostasis
. Voltage-gated calcium channels (CaVs or VGCCs) regulate intracellular calcium homeostasis. . Their activation by electrical activity leads to changes in intracellular Ca2+ levels regulating, depending on the cell type, various processes such as contraction, secretion and gene expression. . While the CaVα1 subunit is the essential component of the calcium channel, the auxiliary β, … [Read more]
The institute was present at the 14th MGFA International Conference on Myasthenia and Related Disorders
The 14th International Conference on Myasthenia Gravis and Related Disorders organised by the Myasthenia Gravis Foundation of America (MGFA) took place from 10 to 12 May 2022 in Miami, USA. It brought together the best experts in myasthenia, including the researchers of team 7 “Myasthenia Gravis: Etiology, Physiopathology & Therapeutical Approaches” of the Institute’s Myology … [Read more]
A post-doctoral position is available at the Institute’s Myology Centre for Research
A two-year fully funded post-doctoral fellowship position sponsored by ANR will be available at the Myology Research Center in the group of Stéphane Vassilopoulos to assess the structure/function relationship of clathrin structures in mechanotransduction and endocytosis. The main objective is to reveal the mechanisms by which muscle cells form clathrin plaques using alternative splicing isoforms … [Read more]
Researchers from the Institute’s NMR laboratory at the ISMRM 2022 conference
The 31st ISMRM (International Society for Magnetic Resonance in Medicine) congress was held in London from 7 to 12 May 2022. Researchers from the NMR Imaging and Spectroscopy Laboratory were able to present their results during several sessions, via digital posters and an oral presentation: Benjamin Marty : Assessment of skeletal muscle extracellular volume fraction … [Read more]
Launch of the 1st European gene therapy clinical trial in LGMD linked to FKRP
The first European gene therapy trial in limb-girdle muscular dystrophy linked to the FKRP gene (LGMD2I/R9) has just started. This is a multicentre phase 1-2 study evaluating the safety, pharmacodynamics, efficacy and immunogenicity of GNT0006, an adeno-associated virus (AAV) vector carrying the human FKRP transgene. This study will consist of two phases: an open-label dose … [Read more]
