Satish B. Moparthi, co-winner of the ‘Grandes Avancées Françaises en Biologie’ award from the French Academie des Sciences

Satish Babu Moparthi, a post-doctoral fellow in the ‘Muscle cell organisation and therapy of centronuclear dominant myopathy’ team at the Center of Research in Myology of the Institute of Myology, co-directed by Stéphane Vassilopoulos, has been awarded the 2025 Grandes Avancées Françaises en Biologie (GAFB) prize, along with Florian Werner, co-author of the article* published in Science reporting their work on axonal endocytosis.

This award, presented each year by the Académie des Sciences to 6 young researchers, aims to highlight different facets of 21st century biology. The awards were presented at the Académie des Sciences in Paris on 17 June in the presence of the co-winners’ research directors Stéphane Vassilopoulos (Centre de Recherche en Myologie, Institut de Myologie) and Christophe Leterrier (Université Aix-Marseille, CNRS).

After a presentation of the research theme by Stéphane Vassilopoulos, Florian Werner described the work that had revealed a hitherto unknown mechanism of endocytosis in the axon, thanks to the combination of two cutting-edge technologies.

This remarkable distinction rewards the fruit of almost 10 years of collaborative work, aimed at combining super-resolution microscopy with electron microscopy to discover new forms of biology**.

Congratulations to the two teams from the Institute of Myology (Paris) and the Institute of Neurophysiopathology (Marseille) for this exceptional work!

 

* Wernert F, Moparthi SB, Pelletier F, Lainé J, Simons E, Moulay G, Rueda F, Jullien N, Benkhelifa-Ziyyat S, Papandréou MJ, Leterrier C, Vassilopoulos S. The actin-spectrin submembrane scaffold restricts endocytosis along proximal axons. Science. 2024 Aug 23;385(6711):eado2032. doi: 10.1126/science.ado2032. Epub 2024 Aug 23. PMID: 39172837.

 

** To find out more about the work, read the interview with S. Vassilopoulos on 23 September 2024.