Researchers from the Laboratory of Physiology and Neuromuscular Evaluation at the Institute of Myology have developed and validated predictive models for the performance of the 6-minute walk test (6MWT) in Pompe disease, using simpler, less demanding tests. In fact, the 6MWT, which is commonly used to assess functional capacity in neuromuscular diseases, can prove difficult for severely affected ambulant patients.
The researchers showed that, among the various tests tested on 74 patients, the 10-metre walk test (10mWT) offers a robust and less exhausting alternative to the 6MWT for assessing walking ability in Pompe disease, particularly for ambulant patients with severe mobility limitations. Its high correlation with the 6MWT and its simplicity of use mean that it can be incorporated into clinical practice and trials.
