An initial study evaluated epidural stimulation of the spinal cord in three patients with type III spinal muscular atrophy (SMA). While motor deficits may persist with Spinraza®, Zolgensma® and Evrysdi®, this technique could directly target the dysfunction of the neuronal circuitry of the spinal cord involved in the progression of the disease.
- The three participants had weakness in their lower limbs and were able to stand and walk.
- Electrodes were placed temporarily in the lumbosacral region on either side of the spinal cord and the spinal cord was stimulated for two hours a day for one month.
- Muscular strength, walking quality and endurance were improved in the various tests.
- All three participants improved the distance covered in the six-minute walking test by at least 20 m.
- Electrophysiological data showed that stimulation improved motor neuron function, with effects occurring during both active and inactive periods of stimulation.
- No adverse events were reported.
