Researchers coordinated by the Institute of Myology have studied the threshold of muscle strength loss beyond which motor function is compromised in the hand:
- 91 patients with Duchenne muscular dystrophy (DMD) and 77 with SMN1-related proximal spinal muscular atrophy (SMA) took part in the study,
- hand grip strength and thumb-index grip strength were measured using dynamometers developed at AIM (MyoGrip and MyoPinch),
- function was assessed using the MoviPlate and the MFM,
This work has made it possible to establish force thresholds, specific to each of the two diseases studied, which are predictive of loss of function. These thresholds will be particularly useful for clinical trials.
