Caution is advised with certain herbal supplements in patients with autoimmune diseases

American doctors have examined the potential risks of over-the-counter herbal products due to their impact on the immune systems of patients with autoimmune conditions such as dermatomyositis:

  • their conclusions are based on a literature review that identified fifteen substances proven (in humans, animals, or cell models) to have an immunostimulatory effect;
  • these non-pharmaceutical products are not subject to the same regulatory requirements as conventional drugs,
  • they are therefore widely used for self-medication, particularly in the United States, to boost immunity,
  • examples include spirulina, ginseng, garlic, and green tea extracts,

In patients with chronic autoimmune diseases, these substances can trigger an exacerbation of disease flare-ups, hence this serious warning.

 

Identifying immunostimulatory herbal supplements that may flare autoimmune skin diseases: a systematic scoping review. Weiner JD, Hill A, Shen C, On A, Werth VP. Lupus Sci Med. 2025 Dec