Chinese researchers studied the potentially positive effects of intraperitoneal corticosteroid injection in a mouse model of Duchenne muscular dystrophy (DMD):
- the working hypothesis was that methylprednisolone (MP) could improve the cognitive and behavioural disorders observed naturally in these diseased mice,
- the study included neuropsychological tests, brain tissue analysis and proteomic profiling,
- MP appears to have had a beneficial effect on cognitive disorders, dendritic arborisation and the re-expression of several proteins of interest (Dp71, GABRA2 and PSD-95).
The authors emphasise the importance of the NF-kB/CCL5 pathway in explaining this phenomenon. Although interesting, these findings are not necessarily transferable to humans.
