German clinicians have studied adverse side effects in patients with autoimmune diseases who have received CAR-T cells targeting the CD19 antigen:
- 39 adult patients, including six with inflammatory myopathy of autoimmune origin, were selected for this retrospective study.
- 30 of them developed a cutaneous and/or renal intolerance syndrome within 10 days of CAR-T cell injection.
- this complication, known as LICATS (local immune effector cell-associated toxicity syndrome), also resolved spontaneously within ten days.
The authors believe that these LICATS cases correspond to the cleansing of immune cells located in the target organs.
