Is corticosteroid therapy effective on cardiac function in DMD? Review

Chinese researchers wanted to know whether the long-term corticosteroid therapy used in Duchenne muscular dystrophy (DMD) could improve cardiac function:

  • their work is based on a critical review of studies in the field published between 2000 and 2024,
  • 21 studies were selected,
  • 13 of which, corresponding to 1,814 DMD patients, argued in favour of a certain efficacy, while 6 showed no difference, and one, a significant worsening.

The authors feel that it is difficult to make a definitive statement at this stage, and that further, better-conducted, longer-term studies are required.

 

The effects of glucocorticoids on cardiac function of patients with Duchenne muscular dystrophy: benefit or not? Cui Y, Shao S, Zhang L et al. Eur J Pediatr. 2025 Apr