A case of acquired and reversible rod myopathy following leukaemia

Researchers at the Créteil Neuromuscular Disease Reference Centre report the rather exceptional case of a patient who developed myopathic symptoms during an immunological complication (graft-versus-host disease or GVHD) that occurred during treatment for leukaemia:

  • the 49-year-old patient was being treated for acute leukaemia with chemotherapy and an allograft when she developed concomitant GVHD and myopathic signs,
  • histology confirmed the existence of acquired rod myopathy (or SLONM for Sporadic Late Onset Nemaline Myopathy),
  • remarkably, she was able to recover from her myopathy after a series of plasma exchanges over several months.

This observation broadens the spectrum of clinical presentations of SLONM.

 

Sporadic late onset nemaline myopathy responsive to plasma exchanges discovered during a Graft-versus-host disease. Souvannanorath S, Borin GU, Redjoul R, et al. Neuromuscul Disord. 2025 May