A new non-invasive biomarker for investigating demyelinating neuropathies

An international consortium led by researchers in Nantes has developed and studied in real life a new non-invasive method for demyelinating neuropathies such as CMT1A, CIDP and anti-MAG neuropathy:

  • shear wave elastography is a non-invasive ultrasound method based on changes in the composition and remodelling of nerve tissue in these degenerative diseases.
  • 20 adult patients took part in this study and their data were compared with a control group of 16 people free of these diseases,
  • Shear wave velocity (SWV) measurements were taken on several occasions, in different positions of the limb segment analysed, resulting in 32 measurements per individual,
  • SWV appears to be markedly increased in demyelinating neuropathies.

Such a method could eventually be used in therapeutic trials.

 

Ultrasound Shear Wave Velocity of Peripheral Nerves: A Possible Non-Invasive Biomarker for Demyelinating Neuropathies. Andrade RJ, Nordez A, Magot A et al. J Peripher Nerv Syst. 2025 Jun