Nerve imaging can help differentiate between acquired and inherited neuropathies

New Zealand researchers used ultrasound to measure the cross-sectional area of the sural and fibular nerves in order to differentiate between acquired and hereditary nerve pathologies:

  • a control group of 34 healthy subjects was set up and compared with three other groups,
  • one consisting of 17 patients with CANVAS syndrome (including ataxia and neuronopathy),
  • the second with 18 patients suffering from CMT2 (axonal form of Charcot-Marie-Tooth disease),
  • and the third with 18 individuals suffering from an acquired length-dependent neuropathy,
  • the nerves of the lower limbs in the hereditary pathologies (CANVAS and CMT2) were significantly thinner than those observed in the acquired pathologies.

This technique is interesting and non-invasive. It may be useful while waiting for genetic tests to clear the pathology.

 

Lower limb nerve ultrasound: A four-way comparison of acquired and inherited axonopathy, inherited neuronopathy and healthy controls. Pelosi L, Coraci D, Mulroy E et al. Muscle Nerve. 2024 Sep.