Ventilatory weaning and myasthenic crisis: the experience of Raymond Poincaré University Hospital

Clinicians in the western Ile-de-France region have retrospectively analyzed the clinical and paraclinical data of 126 myasthenia gravis patients who presented with a first myasthenic episode during the course of their disease, over the period 2001-2018:

  • 18 of the 126 patients (i.e. 14%) could not be weaned off their ventilator after a first extubation attempt, despite a standardized protocol and prior performance of respiratory function tests,
  • several explanatory factors have been identified, such as the absence of a triggering cause for the myasthenic crisis, or marked weakness of the cervical muscles.

Taking these factors into account will help improve the figures for successful weaning.

 

Weaning from mechanical ventilation during myasthenic crisis, a monocentric retrospective study. Mazeraud A, Sivanandamoorthy S, Mancusi R, et al. Sci Rep. 2024 Aug.