Losmapimod fails in facioscapulohumeral myopathy

The initial results of the REACH Phase III placebo-controlled trial evaluating losmapimod in 260 adults with FSHD1 or FSHD2 over one year have just been announced by the Fulcrum Therapeutics laboratory in charge of its development, and they’re not good. Losmapimod failed to meet the trial’s main endpoint, namely to improve measurement of the relative surface area a participant could reach with an outstretched arm. Fulcrum announces discontinuation of development.

 

Fulcrum Therapeutics Announces Topline Results from Phase 3 REACH Clinical Trial of Losmapimod in Facioscapulohumeral Muscular Dystrophy (FSHD). Fulcrum Therapeutics, Communiqué de presse du 12 septembre 2024.