Prevalence of epilepsy in dystrophinopathies revised downwards

According to a retrospective study carried out in Spain on data from 416 patients with Duchenne muscular dystrophy, Becker muscular dystrophy or asymptomatic hyperCKemia :

  • the prevalence of epilepsy was 1.4%, much lower than estimated by various previous studies (3.1% to 7.9%), but slightly higher than in the general population (0.5 to 1% in children and adolescents, 0.5 to 1.6% all ages combined),
  • seizures, focal in half the cases, are controlled by a single antiepileptic, the first prescribed (valproic acid),
  • no correlation was found between the presence of epilepsy and the type of dystrophinopathy, genotype or presence of cognitive disorders.

 

Epilepsy in Duchenne and Becker muscular dystrophies. Armijo Gómez JA, Fernandez-Garcia MA, Camacho A et al. Ann Clin Transl Neurol. 2024 May 1.