Pompe’s disease: beneficial effect of long-term physical activity, especially if training is personalised

The physical fitness of 19 people with moderate Pompe’s disease who took part in a 12-week personalised training programme in the Netherlands in 2011 was compared with that of 10 similar people, in terms of age and duration of illness.

  • Sixteen were considered active according to WHO criteria: 9 participants continued the 2011 exercise programme, two to three times a week for 10 years, and seven belonged to the control group.
  • Thirteen participants were considered physically inactive: 10 stopped the 2011 exercise programme, either immediately or one to four years later, and three were in the control group.
  • The physically active participants had significantly better endurance and muscular strength than the inactive participants.
  • Muscular endurance and strength tended to be better in the active people who continued with the personalised exercise programme than in the active controls.

 

Long-term benefits of physical activity in adult patients with late onset Pompe disease: a retrospective cohort study with 10 years of follow-up. Ismailova G, Wagenmakers MAEM, Brusse E et al. Orphanet J Rare Dis. 2023 Oct 11;18(1):319.