A Franco-Italian team has studied the regeneration processes, fibro-adipogenic precursors and muscle stem cells in 24 muscle biopsies from patients with Duchenne muscular dystrophy (DMD):
- by establishing the myopathological trajectory of DMD, she demonstrated the existence of an increase in fibro-adipogenic cells parallel to a decrease in muscle regenerative capacity;
- this is correlated with impaired activation and expansion of muscle stem cells;
- she also discovered an early senescence of muscle stem cells in DMD.
