Synaptic mechanisms of neurodegeneration and neuroprotection in Amyotrophic Lateral Sclerosis
Mardi 25 février 2020 – 12h-13h30
Francesco Roselli, MD, PhD (Dept. of Neurology, Ulm University, and German Center for Neurodegenerative Diseases (DZNE)-Ulm, Germany)
Hosted by : Maria-Grazia Biferi
Auditorium de l’Institut de Myologie
Bâtiment Babinski
Hôpital de la Pitié-Salpêtrière
entrée 82 bd Vincent Auriol
métro Chevaleret
In vivo electrophysiology and multiplexed chemogenetics demonstrate that, rather than hyperexcitation, ALS MNs experience postsynaptic disruptions and decreased synaptic responses. Synaptic restoration by cAMP/PKA improves disease pathobiochemistry stimulating MN firing, supporting a synaptic failure model for ALS.