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Institut de la Myologie

Newsletter #87

The 26th International Congress of the World Muscle Society, which brings together muscle experts from around the world, was held September 20-24, providing an opportunity to highlight the work of many of the institute’s researchers and clinicians. 

Save the date!

On October 21, at 8:30 p.m., the Casino de Paris will host an exceptional show for the benefit of the Institute of Myology, a research and care center of excellence created by the AFM-Telethon and dedicated to Muscle science and medicine. 

At the initiative of Laura Arend, dancer and choreographer, and Charlotte Ranson, dancer of the Paris Opera, this ballet, specially designed for this evening, will bring together big names from the contemporary and classical scene, notably Yvon Demol or Marion Montin, around original artistic creations and extracts from famous paintings such as the Parc d’Angelin Préljocaj. 

> Watch the teaser of the show, directed by Cédric Klapisch
> Book your seats quickly on the Casino de Paris website!

At the Institute
The Institute has acquired a state-of-the-art electron microscope Interview with N. B. Romero and S. Vassilopoulos - Electron microscopy is an expertise that has been developed at the Institute of Myology since its creation, resulting from the work by global specialists in electron microscopy. This technique requires years of training, not only to operate the equipment, but also to understand what is being observed. Read more

Assessment of energy metabolism and blood flow by NMR during and after exercise Interview with Alfredo Lopez Kolkovsky, the first author of an article published in the journal Magnetic Resonance in Medicine on the assessment of energy metabolism and blood flow by NMR during and after exercise targeting the calf.  Read more

The REDs team supports the International Myotonic Dystrophy Awareness Day The first international awareness day for myotonic dystrophies took place on September 15, 2021. The objective was to highlight these rare diseases to improve diagnosis, care and support, but also to push forward research. Read more

‘Fête de la Science’ – October 5-8 – ‘Les apéros au Labo’ Fancy a special meeting with a scientist? The researchers from the Institute of Myology, Genethon and I-Stem (supported by the AFM-Telethon) will meet you live from their lab as part of the virtual aperitifs of the Fête de la Science. Read more

“1000 researchers in schools” – November 8-December 3 The 9th edition of the scientific information operation for 3rd year and high school students “1000 researchers in schools in France and abroad” will take place between November 8 and December 3. Read more

Upcoming M&M's – Muscle Monday Seminars M&M’s – Muscle Monday Seminars are organized by the Myology Centre for Research, at the Institute of Myology. They are given by videoconference. Next guests: Steve Wilton & Stephen D.R. Harridge. Read more

Our latest news
WMS 2021: Clinicians and researchers from the Institute mobilized for this new edition From September 20 to 24, the 26th International Congress of the World Muscle Society (WMS), brought together muscle experts from around the world, providing the opportunity to highlight the work of many researchers and clinicians at the institute. Read more

When the ERK1/2 pathway disrupts the sarcomere and impairs muscle strength Although the genetic cause of this disorder has been known since the 1990s, the molecular and cellular mechanisms behind loss of strength in these patients remain unclear. Read more

Decrease the time from diagnosis to the start of the treatment with Treatabolome The creation of an open platform drawing up an inventory of all existing treatments for rare genetic diseases, including neuromuscular diseases, is one of the objectives of the European Solve-RD project, which fights diagnostic delay. Read more

DMC related to LMNA: on a large-scale retrospective natural history A retrospective international study coordinated by a team from the Institute of Myology was conducted to describe the natural history of an early-onset form of laminopathy: congenital muscular dystrophy linked to the LMNA gene. Read more

A study by the Institute of Myology has enhanced the phenotypic spectrum due to PLEKHG5 gene mutations In clinical practice, it is not always easy to distinguish between hereditary motor and sensory neuropathy (the prime example being Charcot-Marie-Tooth disease or CMT) and disorders of the lower motor neuron (referenced under different terms such as distal spinal muscular atrophy, distal motor neuronopathy, etc.). Read more

Study of the day-to-day life impact of autoimmune myasthenia gravis from the patient's point of view (MyRealWorld MG) This prospective, observational, digital longitudinal study, lasting 2 years, aims to explore the impact of MG in the day-to-day life of adult patients using data declared by the patients themselves to understand and respond to their own needs. Read more

Analysis of high-throughput digital images reveals distinct patterns of dystrophin expression in patients with dystrophinopathy Researchers have been tackling dystrophin expression using both Western blot and an image analysis platform. automated high-throughput on skeletal muscle biopsies from DMD, BMD and DMD / BMD intermediates. Read more

A review of the involvement of Dynamin 2 in cancers sheds light on a promising therapeutic target Dynamin 2 (DNM2) is a large ubiquitously expressed GTPase, well known for its role in vesicle formation in endocytosis and intracellular membrane trafficking, also acting as a cytoskeletal regulator. Read more

More breaking news
The first Solve-RD report confirms the benefit of an exceptional European research project focusing on rare diseases More than 300 experts from 15 countries, including clinical practitioners, geneticists, patient representatives and researchers, are taking part in the Solve-RD research project, funded by European Union grants over 2018-2022. Read more

Efgartigimod reaches phase III in myasthenia gravis A disorder affecting the neuromuscular junction, autoimmune myasthenia has benefited from relatively intensive therapeutic research for a rare disease, with more than 50 clinical trials in progress or in preparation registered on the ClinicalTrials site as of the end of July 2021. Read more

Myasthenia gravis
Inflammatory myopathies
Congenital muscular dystrophies
Spinal muscular atrophy
Duchenne muscular dystrophy
Basic research and other disorders
In brief
DM1 and DM2: Advances in research « Advances in Steinert’s disease » and « Advances in myotonic dystrophy type 2 » are two new documents presenting research news in myotonic dystrophies field : international symposia, ongoing clinical trials or studies, scientific and medical publications… They can be downloaded. Read more

World Duchenne Awareness Day: spread the word September 7, 2021, the 8th World Duchenne Awareness Day was a reminder of the importance of creating opportunities to improve the lives of adults living with Duchenne muscular dystrophy . Read more

14th international conference on Cachexia, Sarcopenia and Muscle Wasting - Dec. 10-12, 2021 This conference will take place in Ljuilbjana, Slovenia, from December 10 to 12, 2021. The deadline for abstract submission will be on the 15th of October 2021. Read more

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Every two months, the newsletter from the Institute of Myology informed you on developments in myology research, with a summary of the latest scientific, medical, political and community news about neuromuscular diseases. You can read our newsletter by subscribing. You can unsubscribe here.
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This newsletter is about the medical-scientific actuality of the Association Institute of Myology. It is published every two months. Chief Editor: Vincent Varlet. Editorial Board: Bertrand Fontaine; Emmanuelle Guiraud; Delphine Olivier; J. Andoni Urtizberea; Vincent Varlet. Editorial staff: Anne Berthomier. Also participate: Lawrence Chambers; Hala Alameddine. Do you have any questions? Would you like to share some news? Please contact us. © 2021 - AFM - Association Institut de Myologie. ISSN 1772-9866 You are receiving this email because you have subscribed to the Association Institute of Myology’s newsletter. You no longer wish to receive our newsletter? You can unsubscribe from our mailing list by clicking here.