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Institut de la Myologie

Newsletter #92

After a long break for the summer holidays, welcome to the latest issue of our newsletter!

The international congresses Myology 2022 and mitoNice are about to begin, the Institute of Myology will be very present through its speakers, moderators and posters.

We look forward to seeing you at the Myology 2022 conference next Monday. We will be waiting for you at booth #10 in the exhibition hall.

> You will find all the presentations of our experts on our website, updated every day.

At the institute
Report of the 2022 AcadeMYO session Andoni Urtizberea reports on the 2022 session of AcadeMYO, the fully virtual version of the Institute’s Myology Summer School, which was held from 11 to 13 July. Read more

The REDs team gathered for the IDMC-13 conference The 13th International Myotonic Dystrophy Consortium Congress (IDMC-13) took place from 22 to 25 June 2022. It should have been held both on-site in Osaka, Japan, and online, but the health situation led the organisers to opt for a digital-only version. Read more

Clinicians from the Institute at the 8th EAN Congress The 8th Congress of the European Academy of Neurology was held from 25 to 28 June in Vienna, Austria. Several clinicians from the Institute of Myology participated in the congress as session chairperson (Dr. Giorgia Querin), in a conversation symposium (Dr. Anthony Béhin), in oral communications (Dr. Giorgia Querin) or in case-based workshops (Dr. Tanya Stojkovic). Read more

The Institute’s clinicians and researchers in force at the ICNMD 2022 conference in Brussels The International Congress on Neuromuscular Diseases (ICNMD) was held in Brussels from 5 to 9 July 2022. The Institute of Myology was very well represented, both in terms of clinical and fundamental research. Read more

ERN EURO-NMD webinar, July 7th: Mario Gomes-Pereira & Arnaud Klein Mario Gomes-Pereira and Arnaud Klein (REDs team, MCR) gave a webinar on 7 July: "Myotonic dystrophy type 1: from DNA repeat expansion and toxic RNA to the development of new therapeutic approaches". A recording of the webinar is available on the page. Read more

Our latest news
Muscle regeneration affects AAV vector transcription As part of the research on the molecular mechanisms that impact AAV vector expression in pathological muscle, the group of Sofia Benkhelifa-Ziyyat and Stéphanie Lorain from the Institute’s Myology Centre for Research evaluated the impact of the necrosis-regeneration process on AAV vector expression efficiency in Duchenne muscle. Read more

A new biomarker for fibrosis in DMD The fibrosis constantly observed in the muscle of patients suffering from Duchenne muscular dystrophy (DMD) remains largely an enigma and is not easily accessible to a specific therapy. Read more

Impact of frontal lobe damage on social dysfunction in DM1 Myotonic dystrophy type 1 (DM1) is an autosomal dominant multisystemic disease that affects muscular and extra-muscular systems, including the central nervous system. Brain damage in DM1 is associated with subtle cognitive and behavioural disorders, with a major impact on socio-professional adaptation. Read more

DM1: RNA toxicity alters astrocyte morphology, adhesion and migration Mario Gomes-Pereira and his team have just published a paper in Nature Communications on changes in astrocytes caused by mutated RNA toxicity in mice and humans with myotonic dystrophy type 1. Read more

Identification of a new communication pathway in the neuromuscular junction A study conducted by the “Neuromuscular connectivity in health and pathologies” team led by Laure Strochlic and Bertrand Fontaine at the Institute’s Myology Centre for Research has just been published in Science Signaling*. This work demonstrates the existence of a new communication pathway in the neuromuscular junction that is active both during embryogenesis and at the adult stage. Read more

New TMP3 variant: the phenotypic range of TMP3-related congenital myopathy expands Mutations in the tropomyosin 3 (TPM3) gene are associated with autosomal dominant and recessive nemaline 1 (NEM1) myopathy, congenital myopathy with disproportionate muscle fibre types and cap myopathy. Read more

More breaking news
Searching for the optimal corticosteroid therapy in DMD Although long-term corticosteroid therapy is a commonly accepted standard of care in DMD, its modalities are still debated. An essai international multicentrique attempted to answer this question by comparing several types of corticosteroids in a population of 196 children. Read more

Two American teams, one from Boston and the other from New York, have compared their points of view on the thorny question of whether or not to treat so-called “presymptomatic” subjects carrying 4 or more copies of the SMN2 gene. Two American teams, one from Boston and the other from New York, have compared their points of view on the thorny question of whether or not to treat so-called “presymptomatic” subjects carrying 4 or more copies of the SMN2 gene. Read more

Inflammatory myopathies
Duchenne and Becker muscular dystrophies
Spinal muscular atrophy
Charcot-Marie-Tooth disease
Facioscapulohumeral muscular dystrophy
Basic research and other disorders
In brief
International guidelines for heart rhythm disorders in NMD International specialists in neuromuscular pathology associated with cardiologists have established practical guidelines for rhythm disorders encountered in neuromuscular diseases. Read more

Upcoming webinar organized by EURO-NMD Upcoming webinar organized by the European network EURO-NMD: 21st September, "Mitochondrial movements disorders" and 29th September, "Mitochondrial optical neuropathies" by Dr. Chiara la Morgia (Bologna, Italy) Read more

49th European Muscle Conference - Prague, Czech Republic - 22-26 September 2022 The 49th European Muscle Conference will be held in Prague, Czech Republic from 22 to 26 September 2022. Read more

Job opportunities The Institute of Myology is recruiting a Clinical research associate (CRA) for I-Motion, the MCR offers a post-doc position. The European Reference Network (ERN) EURO-NMD is looking for a Senior Project Manager (M/F). Read more

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Every two months, the newsletter from the Institute of Myology informed you on developments in myology research, with a summary of the latest scientific, medical, political and community news about neuromuscular diseases. You can read our newsletter by subscribing. You can unsubscribe here.
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This newsletter is about the medical-scientific actuality of the Association Institute of Myology. It is published every two months. Chief Editor: Vincent Varlet. Editorial Board: Fabrice Chrétien; Bertrand Fontaine; Emmanuelle Guiraud; Delphine Olivier; J. Andoni Urtizberea; Vincent Varlet. Editorial staff: Anne Berthomier. Do you have any questions? Would you like to share some news? Please contact us. © 2022 - AFM - Association Institut de Myologie. ISSN 1772-9866 You are receiving this email because you have subscribed to the Association Institute of Myology’s newsletter. You no longer wish to receive our newsletter? You can unsubscribe from our mailing list by clicking here.