{"id":2820,"date":"2022-11-30T16:06:00","date_gmt":"2022-11-30T14:06:00","guid":{"rendered":"https:\/\/www.institut-myologie.org\/imotion\/?p=2820"},"modified":"2023-01-16T10:26:19","modified_gmt":"2023-01-16T08:26:19","slug":"demarrage-de-lessai-sapphire-a-i-motion","status":"publish","type":"post","link":"https:\/\/www.institut-myologie.org\/imotion\/2022\/11\/30\/demarrage-de-lessai-sapphire-a-i-motion\/","title":{"rendered":"D\u00e9marrage de l\u2019essai SAPPHIRE \u00e0 I-Motion"},"content":{"rendered":"\n<p>L\u2019essai SAPPHIRE est un essai international de phase III, randomis\u00e9, en double aveugle, contre placebo qui va \u00e9valuer les effets d\u2019un double traitement&nbsp;:<\/p>\n\n\n\n<ul class=\"wp-block-list\"><li>l\u2019apitegromab (un anti-myostatine d\u00e9velopp\u00e9 par <em>Scholar Rock<\/em>) inject\u00e9 en intraveineuse toutes les 4 semaines pendant un an,<\/li><li>en compl\u00e9ment d\u2019un traitement par nusinersen ou risdiplam,<\/li><li>chez des patients atteints de SMA de type II ou III et non marchants, 156 \u00e2g\u00e9s de 2 \u00e0 12 ans et 48 \u00e2g\u00e9s de 13 \u00e0 21 ans.<\/li><\/ul>\n\n\n\n<p>L\u2019apitegromab a d\u00e9j\u00e0 montr\u00e9 <a href=\"https:\/\/www.institut-myologie.org\/2021\/10\/15\/wms2021-et-sma-entre-therapie-innovante-et-biotherapie\/\" target=\"_blank\" rel=\"noreferrer noopener\">des r\u00e9sultats positifs sur la fonction motrice<\/a> au cours de l\u2019essai TOPAZ aupr\u00e8s de 58 patients atteints de SMA de type II ou III, \u00e2g\u00e9s de 2 \u00e0 21 ans.<\/p>\n\n\n\n<p><\/p>\n\n\n\n<p>Clinicaltrials.gov&nbsp;: <a href=\"https:\/\/clinicaltrials.gov\/ct2\/show\/NCT05156320?term=sapphire&amp;cond=Spinal+Muscular+Atrophy&amp;draw=2&amp;rank=1\" target=\"_blank\" rel=\"noreferrer noopener\">NCT05156320<\/a><\/p>\n","protected":false},"excerpt":{"rendered":"<p>L\u2019essai SAPPHIRE est un essai international de phase III, randomis\u00e9, en double aveugle, contre placebo qui va \u00e9valuer les effets d\u2019un double traitement&nbsp;: l\u2019apitegromab (un anti-myostatine d\u00e9velopp\u00e9 par Scholar Rock) inject\u00e9 en intraveineuse toutes les 4 semaines pendant un an, en compl\u00e9ment d\u2019un traitement par nusinersen ou risdiplam, chez des patients atteints de SMA de &hellip; <a href=\"https:\/\/www.institut-myologie.org\/imotion\/2022\/11\/30\/demarrage-de-lessai-sapphire-a-i-motion\/\">Continued<\/a><\/p>\n","protected":false},"author":3,"featured_media":0,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"_acf_changed":false,"footnotes":""},"categories":[5,1],"tags":[],"class_list":["post-2820","post","type-post","status-publish","format-standard","hentry","category-actualites-cliniques","category-non-classifiee"],"acf":[],"yoast_head":"<!-- This site is optimized with the Yoast SEO plugin v27.1.1 - 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