Quantitative muscle imaging with compensation for RF field inhomogeneities, dB/dm non-linearities, improved intrinsic contrast quality, co-registration of successive examinations, tissue segmentation, development of user-friendly processing tools;

Perfusion quantitation with ASL;

Metabolic imaging protocols;

Diffusion imaging protocols and their adaptations to the investigation of muscle architecture.

 

Phophorus magnetization transfer;
Chemical Shift Imaging (CSI);
Development of imaging protocols for the diagnosis of muscular disorders;
Conception of a new amagnetic ergometer with extended capacities of monitoring exercise in
the magnet;
Development of NMR probes for interleaved acquisitions of perfusion and energy metabolism
during muscle contractions in the small animal

Human studies
Pompe disease: natural history and enzymatic therapy;
Type III glycogenosis: natural history;
Microangiopathy in type-2 diabetic patients;
Evaluation of a therapeutic treatment in Friedreich
ataxia;
Effect of an anapleurotic treatment in Huntington’s
disease;
Electrostimulation protocol on healthy volunteer leg
combined with multi-parametric functional NMR
acquisitions for future clinical applications
Animal disease studies
Characterization of the natural history of the Golden

 

Characterization of the natural history of the Golden Retriever Muscular Dystrophy (GRMD)
dog;
Pre-clinical evaluation of new therapeutics in the GRMD dog;
Electrostimulation of mouse muscle to evaluate energetic metabolism in mdx mouse;
Development of imaging protocols for non-invasive monitoring cell therapy.