Current research programs comprise:
• quantitative muscle imaging at 3T, with compensation for RF field inhogeneities, dB/dm non-linearities, improved intrinsic contrast quality, co-registration of successive examinations,
tissue segmentation, development of user-friendly processing tools;
• to take the adequates measures in order to ensure proper functioning of the 10-year old Bruker Biospec spectrometer;
• to set up protocols for perfusion quantitation with ASL at 3T ;
• to set up metabolic imaging protocols at 3T;
• to set up diffusion imaging protocols and their adaptations to the investigation of muscle architecture;
• to study muscle energetics and regulation of muscle perfusion during aging;
• to study the coupling between perfusion and energy metabolism, local heterogeneities of this coupling in healthy subjects and in diseases;
• to participate to clinical research protocols and to contribute with the production of NMR imaging and/or spectroscopy: Pompe disease : natural history and enzymatic therapy ; Type III glycogenosis: natural history; microangiopathy in type-2 diabetic patients; growth hormone therapy in a pediatric population under chronic steroid therapy ; benzofibrate treatment of carnityl-palmitoyl transferase deficiency ; AAV-based treatment of gamma sarcoglycanopathy; myoblast transplantation in FSH and OP dystrophies;