Newsletter :: Institut de Myologie
#15
Bimonthly Newsletter - June/July 2008  
myology 2008
:: Congress highlights
  Stem cells - May 27th
  Heart - May 28th
  Laminopathies and dystrophinopathies - May 28th
  Motor neuron diseases - May 29th
  Therapeutic strategies - May 30th
:: Questions to scientists
:: Latest research highlights
:: Subscription
Special edition
bandeau
Thomas Voit
NEARLY one thousand researchers working on various aspects of myology met this year in Marseille for the 3rd International Congress of myology.
AT the end of this scientific event, we observed advances and openings: new drugs, the arrival of new molecular treatment principles and several action principles are currently progressing into treatment principles. Furthermore, for a therapy principle, other diseases are becoming eligible (eg exon skipping for some dysferlinopathies). 
IT is also clear that the science and clinical practice of myology form a distinct field of medicine, in the same way that neurology became separated from internal medicine over a hundred years ago. This is evident not only because of the increasing knowledge and the arrival of basic researchers and clinicians, but also because of treatments that in themselves create a dynamism favouring the recognition of myology as a discipline in its own right.
 
Thomas Voit President, Myology 2008
Medical and scientific director of the Myology Institute (Paris, France)
http://www.myology2008.org/en/
   Congress highlights, day by day

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Stem cells - Tuesday, May 27th

  • Myostatin – the factor that makes all the difference (Christophe Marcelle)
  • Duchenne muscular dystrophy – towards the first clinical trial by mesoangioblasts in humans (Giulio Cossu)

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Heart - Wednesday, May 28th am

  • Embryonic stem cells to repair the heart – from rat to monkey (Michel Pucéat)
  • A new in vitro model for testing heart therapies (Christelle Monville)
  • Melatonin boosts heart cell therapy (Angelo Parini)

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Laminopathies and dystrophinopathies - Wednesday, May 28th pm

  • Progeria : setting up a clinical protocol (Nicolas Lévy)
  • Nanoparticles – a new mode of administration for exon skipping (Alessandra Ferlini)
  • Myozyme® and adult Pompe disease – encouraging results to be confirmed (Pascal Laforêt)

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Motor neuron diseases - Thursday, May 29th

  • Spinal amyotrophy (SMA): spinal cord within reach of the gene (Martine Barkats)

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Therapeutic strategies based on knowledge of molecular biology of the diseases - Friday 30th

  • Exon skipping in Duchenne myopathy – more details about a UK trial (George Dickson)
  • Exon skipping by oligonucleotides: startup of a phase I/II trial by systemic administration (Judith van Deutekom)
  • Exon skipping by AAV-U7: results in the dog (Luis Garcia)
  • Discovery of a mini-dysferlin (Martin Krahn)
  • Identification of the major actors in the molecular mechanism of facio-scapulo-humeral muscular dystrophy (FSH) – DUX4, PITX1 and DUX4c (Alexandra Belayew)

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   Questions to scientists

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Listen to interviews (in French or English) with researchers present at Myology 2008 who talked to us about their backgrounds and current research projects.

  • Thomas Voit, President of Myology 2008 and Medical and scientific director of the Myology Institute (Paris, France) (in French)
  • Serge Braun, AFM scientific Director (in French)
  • Christophe Marcelle, France (in French)
    Lecture : Skeletal muscle morphogenesis and growth. A bird's eye view (Tuesday 27 may)
  • Shin'ichi Takeda, Japon
    Lecture : Characterization of adult progenitor cells in skeletal muscle (Tuesday 27 may)
  • Giulio Cossu, Italy
    Lecture : Toward the cell therapy for muscle dystrophies (Tuesday 27 may)
  • Christian Pinset, France (in French)
    Lecture : Is there a future for muscle repair by cell therapy (Tuesday 27 may)
  • Kenneth Chien, USA
    Lecture : How to make a herat : multipotent cardiovascular progenitors in development and disease (Wednesday 28 may)
  • Denis Duboc, France (in French)
    Lecture : Perindopril treatment in DMD and prevention of sudden death in laminopathies (Wednesday 28 may)
  • Gisèle Bonne, France (in French)
    Lecture : Animal models in laminopathies (Wednesday 28 may)
  • Jean-Thomas Vilquin, France (in French)
    Lecture : Myoblast transplantation from human embryonic stem cells and cardiac regeneration (Wednesday 28 may)
  • Yvan Torrente, Italy (in French)
    Lecture : Autologous transplantation of engineered muscle derived CD133+ stem cells (Wednesday 28 may)
  • Steve Wilton, Australia
    Lecture : Splice intervention therapies for muscle diseases (Wednesday 28 may)
  • Martine Barkats, France (in French)
    Lecture : AAV-mediated gene transfer in the central nervous system of a feline model of SMA (Thursday 29 may)
  • George Dickson, UK
    Lecture : Antisense and RNAi technologies : from natural phenomena to new therapeutics (Friday 30 may)
  • Luis Garcia, France (in French)
    Lecture : Muscle function recovery in dystrophic dog after exon skipping gene therapy (Friday 30 may)
  • Judith van Deutekom, The Netherlands
    Lecture : Pre-clinical and clinical development of 20MePS antisense oligonucleotides for DMD (Friday 30 may)
  • Daniel Schümperli, Switzerland
    Lecture : Correction of SMN2 splicing by a bifunctional U7 snRNA complements (Friday 30 may)

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   Latest research highlights

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Discover our selection of scientific and medical publications in the fields of myology and neuromuscular diseases: a summary of each publication aimed at the general reader, highlighting the main points of the article and the authors’ conclusions is provided.

  • Gene transfer by helper-dependent adenovirus vector into multiple muscles: an effective treatment for muscular dystrophy? - Read
  • Scientists unveil potential approach to treat spinal muscular atrophy - Read
  • Viagra: a new approach to protect the hearts of muscular dystrophy sufferers? - Read
  • Drug Targets Identified In Limb-Girdle Muscular Dystrophy - Read
  • Toxic RNA contributes to neurodegeneration - Read
  • New insights on spinal muscular atrophy - Read

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   Subscription

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Discover our selection of scientific and medical publications in the field of myology and of neuromuscular diseases.

The bimonthly Newsletter of the Institute of Myology keeps you up to date with developments in myology research, and presents a summary of the latest scientific, medical, political and associative news concerning neuromuscular diseases.

You can access our Newsletter by connecting directly to the Institute of Myology website, or by subscribing.
 
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